Acquired TTP

A patient with Acquired TTP will have a trigger that sets off the TTP episode.

As described in What is TTP? the ADAMST13 enzyme does not work correctly in some people. If you have acquired TTP you will have been susceptible for some (as yet unknown) reason to getting the condition, and the trigger will have brought on the episode of TTP.

Here are some known triggers:

  • Combine contraceptive pill
  • Viral infections
  • Pregnancy
  • Quinnine
  • HIV
  • Ticlopidine
  • Interferon
  • Simvastatin

However in most patients with acquired TTP, they have no obvious triggering factor.


TTP affects both male and females, 2/3rds of patients are females and all age groups although it is most commonly seen in the 3rd and 4th decade.

The best-known treatment for TTP is plasma exchange therapy. You can read more about this in the Therapies section.

Whole platelets should not be given to a TTP patient as this effectively feeds the disease.